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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
12.42
Human Site:
Y299
Identified Species:
19.52
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
Y299
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
C
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
T277
Q
L
L
L
E
M
L
T
F
N
P
H
K
R
I
Dog
Lupus familis
XP_852360
326
36788
Y299
Y
S
A
L
S
H
P
Y
F
H
D
L
E
R
C
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
Y299
Y
G
A
L
N
H
P
Y
F
Q
D
L
E
R
Y
Rat
Rattus norvegicus
P35426
303
33780
T277
Q
L
L
L
E
M
L
T
F
N
P
L
K
R
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
F176
S
A
L
S
H
P
Y
F
H
D
L
E
K
G
K
Chicken
Gallus gallus
P13863
303
34670
L268
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
Frog
Xenopus laevis
Q91727
319
35666
T277
D
L
L
L
A
M
L
T
F
S
P
Q
K
R
I
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
L275
D
E
L
G
K
S
L
L
L
S
L
D
S
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
N290
K
Y
A
D
D
L
L
N
K
M
L
S
Y
D
L
Honey Bee
Apis mellifera
XP_391955
457
50351
G431
Y
G
L
D
L
I
K
G
M
L
T
F
N
P
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
F299
E
Q
G
L
L
H
G
F
F
G
D
E
E
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
L268
L
D
L
L
S
K
M
L
R
Y
E
P
S
K
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
L268
V
D
L
L
S
K
M
L
L
M
D
P
T
K
R
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
L272
D
P
R
G
I
D
L
L
D
K
L
L
A
Y
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
20
93.3
N.A.
80
26.6
N.A.
0
20
20
0
N.A.
6.6
6.6
N.A.
33.3
P-Site Similarity:
100
N.A.
26.6
93.3
N.A.
86.6
33.3
N.A.
20
26.6
33.3
0
N.A.
6.6
6.6
N.A.
40
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
13.3
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
27
0
7
0
0
0
0
0
0
0
14
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
14
% C
% Asp:
20
20
0
14
7
7
0
0
7
7
40
7
0
7
14
% D
% Glu:
7
7
0
0
14
0
0
0
0
0
7
14
27
7
0
% E
% Phe:
0
0
0
0
0
0
0
14
47
0
0
7
0
0
0
% F
% Gly:
0
14
7
14
0
0
7
7
0
7
0
0
0
7
0
% G
% His:
0
0
0
0
7
27
0
0
7
7
0
7
0
0
7
% H
% Ile:
0
0
0
0
7
7
0
0
7
0
0
0
0
0
20
% I
% Lys:
7
0
0
0
7
20
7
0
7
7
0
0
27
20
7
% K
% Leu:
14
20
60
67
14
7
40
34
14
7
27
34
0
0
7
% L
% Met:
0
0
0
0
0
20
20
0
7
14
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
7
0
14
0
0
7
0
0
% N
% Pro:
0
7
0
0
0
7
20
0
0
0
20
20
0
7
0
% P
% Gln:
14
7
0
0
0
0
0
0
0
14
0
7
0
0
0
% Q
% Arg:
0
0
7
0
0
0
0
0
7
0
0
0
0
40
20
% R
% Ser:
7
14
0
7
34
7
0
0
0
14
0
7
14
0
7
% S
% Thr:
0
0
0
0
0
0
0
20
0
0
7
0
7
7
0
% T
% Val:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
27
7
0
0
0
0
7
20
0
14
0
0
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _